KIRREL3 Antibody (PACO60216)
- SKU:
- PACO60216
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KIRREL3 Antibody (PACO60216) |
| Antibody SKU: | PACO60216 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Kin of IRRE-like protein 3 protein (200-343AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of HepG2 cells with PACO60216 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. |
| Synonyms: | Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3], KIRREL3, KIAA1867 NEPH2 |
| UniProt Protein Function: | KIRREL3: Could be involved in the hematopoietic supportive capacity of stroma cells. A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 11q24Cellular Component: axon; plasma membrane; extracellular region; integral to membrane; dendritic shaftMolecular Function: protein bindingBiological Process: pontine nucleus development; neuron migration; hemopoiesis; neurite morphogenesisDisease: Mental Retardation, Autosomal Dominant 4 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in this gene are associated with mental retardation autosomal dominant type 4 (MRD4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q8IZU9 |
| NCBI GenInfo Identifier: | 26006461 |
| NCBI Gene ID: | 84623 |
| NCBI Accession: | NP_115920 |
| UniProt Secondary Accession: | Q8IZU9,Q3MIJ7, Q6UWJ9, Q6UWL5, Q96JG0 |
| UniProt Related Accession: | Q8IZU9 |
| Molecular Weight: | Predicted: 64; 84 kDaObserved: 60 kDa |
| NCBI Full Name: | kin of IRRE-like protein 3 isoform 1 |
| NCBI Synonym Full Names: | kin of IRRE like 3 (Drosophila) |
| NCBI Official Symbol: | KIRREL3 |
| NCBI Official Synonym Symbols: | MRD4; KIRRE; NEPH2; PRO4502 |
| NCBI Protein Information: | kin of IRRE-like protein 3; nephrin-like 2; nephrin-like protein 2; kin of irregular chiasm-like protein 3 |
| UniProt Protein Name: | Kin of IRRE-like protein 3 |
| UniProt Synonym Protein Names: | Kin of irregular chiasm-like protein 3; Nephrin-like protein 2 |
| Protein Family: | |
| UniProt Gene Name: | KIRREL3 |
| UniProt Entry Name: | KIRR3_HUMAN |
| Antibodies |
| KIRREL3 Antibody (PACO10115) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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