KIR2DL5B Antibody (PACO04693)
- SKU:
- PACO04693
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KIR2DL5B Antibody |
| Antibody SKU: | PACO04693 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human CD158f2. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | KIR2DL5B; CD158F; CD158F2; KIR2DL5; KIR2DLX; Killer cell immunoglobulin-like receptor 2DL5B; CD158 antigen-like family member F2; Killer cell immunoglobulin-like receptor 2DLX; CD antigen CD158f2 |
| UniProt Protein Function: | Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.CautionThe KIR2DL5B gene is not directly represented on the GRCh38 primary reference genome assembly but on alternate loci of that assembly. |
| UniProt Protein Details: | |
| NCBI Summary: | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NHK3 |
| NCBI GenInfo Identifier: | 74760352 |
| NCBI Gene ID: | 553128 |
| NCBI Accession: | Q8NHK3.1 |
| UniProt Secondary Accession: | Q8NHK3,B0L651 |
| UniProt Related Accession: | Q8NHK3 |
| Molecular Weight: | 40,695 Da |
| NCBI Full Name: | Killer cell immunoglobulin-like receptor 2DL5B |
| NCBI Synonym Full Names: | killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5B |
| NCBI Official Symbol: | KIR2DL5B |
| NCBI Official Synonym Symbols: | KIR2DL5; KIR2DLX; KIR2DL5.2 |
| NCBI Protein Information: | killer cell immunoglobulin-like receptor 2DL5B |
| UniProt Protein Name: | Killer cell immunoglobulin-like receptor 2DL5B |
| UniProt Synonym Protein Names: | CD158 antigen-like family member F2; Killer cell immunoglobulin-like receptor 2DLX; CD_antigen: CD158f2 |
| Protein Family: | |
| UniProt Gene Name: | KIR2DL5B |
| UniProt Entry Name: |
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