KIDINS220 Antibody (PACO19898)
- SKU:
- PACO19898
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KIDINS220 Antibody (PACO19898) |
| Antibody SKU: | PACO19898 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Synthetic peptide of human KIDINS220 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Raji cells, Hela cells, Primary antibody: PACO19898(KIDINS220 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds. |
| Background: | Ankyrin repeat-rich membrane-spanning protein (ARMS), also designated kinase D-interacting substance 220 or Kidins220, is a highly conserved protein containing multiple domains, including four putative transmembrane domains and several ankyrin repeats. ARMS is expressed in regions rich in neurotrophin (Trk) and ephrin (Eph) receptors, such as the brain and neuroendocrine cells (where it concentrates at the tip of neurites) and in plastic areas of the adult brain. It is also detected in peripheral blood immature dendritic cells and PC12 cells. ARMS functions as a substrate for protein kinase D and is a downstream target for both Trk and Eph receptors. It is a highly conserved protein, which suggests it has an evolutionary conserved role. The gene encoding for the protein maps to chromosome 2p24. |
| Synonyms: | kinase D-interacting substrate, 220kDa |
| UniProt Protein Function: | KIDINS220: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 2p24 Cellular Component: nucleoplasm; protein complex; membrane; late endosome; integral to membrane; cytosol Molecular Function:PDZ domain binding Biological Process: activation of MAPKK activity; nerve growth factor receptor signaling pathway; in utero embryonic development; dendrite morphogenesis; cytoplasmic transport |
| UniProt Code: | Q9ULH0 |
| NCBI GenInfo Identifier: | 172044825 |
| NCBI Gene ID: | 57498 |
| NCBI Accession: | Q9ULH0.3 |
| UniProt Secondary Accession: | Q9ULH0,Q4VC08, Q6MZU2, Q9H889, Q9H9E4, Q9NT37, Q9UF42 A1L4N4, |
| UniProt Related Accession: | Q9ULH0 |
| Molecular Weight: | 1771 |
| NCBI Full Name: | Kinase D-interacting substrate of 220 kDa |
| NCBI Synonym Full Names: | kinase D-interacting substrate, 220kDa |
| NCBI Official Symbol: | KIDINS220 |
| NCBI Official Synonym Symbols: | ARMS |
| NCBI Protein Information: | kinase D-interacting substrate of 220 kDa; truncated KIDINS220; ankyrin repeat-rich membrane spanning; ankyrin repeat-rich membrane-spanning protein |
| UniProt Protein Name: | Kinase D-interacting substrate of 220 kDa |
| UniProt Synonym Protein Names: | Ankyrin repeat-rich membrane-spanning protein |
| Protein Family: | Kinase D-interacting substrate |
| UniProt Gene Name: | KIDINS220 |
| UniProt Entry Name: | KDIS_HUMAN |
| Antibodies |
| KIDINS220 Antibody (PACO10091) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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