KDM6B Antibody (PACO18593)
- SKU:
- PACO18593
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KDM6B Antibody (PACO18593) |
| Antibody SKU: | PACO18593 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human KDM6B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: PACO18593(KDM6B Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 minutes. |
| Background: | KDM6B (Lysine demethylase 6B) is a 1,679 amino acid, nuclear protein that contains one JmjC domain and belongs to the highly conserved JmjC domain-containing protein family. Functioning as a histone demethylase, JMJD3 uses iron and ascorbate as cofactors to demethylate dimethylated and trimethylated Lys-27 residues of Histone H3, thereby playing an important role in the modification of the histone code. |
| Synonyms: | lysine (K)-specific demethylase 6B |
| UniProt Protein Function: | JMJD3: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Oxidoreductase; EC 1.14.11.-Chromosomal Location of Human Ortholog: 17p13.1Cellular Component: nucleoplasm; nucleusMolecular Function: histone demethylase activity; protein bindingBiological Process: cardiac muscle cell differentiation; endothelial cell differentiation; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O15054 |
| NCBI GenInfo Identifier: | 313104309 |
| NCBI Gene ID: | 23135 |
| NCBI Accession: | O15054.4 |
| UniProt Secondary Accession: | O15054,Q96G33, C9IZ40 |
| UniProt Related Accession: | O15054 |
| Molecular Weight: | 180,702 Da |
| NCBI Full Name: | Lysine-specific demethylase 6B |
| NCBI Synonym Full Names: | lysine demethylase 6B |
| NCBI Official Symbol: | KDM6B |
| NCBI Official Synonym Symbols: | JMJD3 |
| NCBI Protein Information: | lysine-specific demethylase 6B |
| UniProt Protein Name: | Lysine-specific demethylase 6B |
| UniProt Synonym Protein Names: | JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM6B |
| UniProt Entry Name: | KDM6B_HUMAN |
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