KDM6A Antibody (PACO55826)
- SKU:
- PACO55826
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KDM6A Antibody (PACO55826) |
| Antibody SKU: | PACO55826 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Lysine-specific demethylase 6A protein (620-749AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO55826 diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. |
| Synonyms: | Lysine-specific demethylase 6A (EC 1.14.11) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein), KDM6A, UTX |
| UniProt Protein Function: | UTX: a nuclear protein that contains 8 tetratrico peptide repeat (TPRs). Processes involving TPR proteins include cell-cycle control, transcription repression, stress response, protein kinase inhibition, mitochondrial and peroxisomal protein transport and neurogenesis. Protein type: Oxidoreductase; EC 1.14.11.-Chromosomal Location of Human Ortholog: Xp11.2Cellular Component: histone methyltransferase complex; nucleoplasm; nucleusMolecular Function: histone demethylase activityBiological Process: histone H3-K4 methylationDisease: Kabuki Syndrome 1; Kabuki Syndrome 2 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014] |
| UniProt Code: | O15550 |
| NCBI GenInfo Identifier: | 206729942 |
| NCBI Gene ID: | 7403 |
| NCBI Accession: | O15550.2 |
| UniProt Secondary Accession: | O15550,Q52LL9, Q5JVQ7 |
| UniProt Related Accession: | O15550 |
| Molecular Weight: | 154,177 Da |
| NCBI Full Name: | Lysine-specific demethylase 6A |
| NCBI Synonym Full Names: | lysine demethylase 6A |
| NCBI Official Symbol: | KDM6A |
| NCBI Official Synonym Symbols: | UTX; KABUK2; bA386N14.2 |
| NCBI Protein Information: | lysine-specific demethylase 6A |
| UniProt Protein Name: | Lysine-specific demethylase 6A |
| UniProt Synonym Protein Names: | Histone demethylase UTX; Ubiquitously-transcribed TPR protein on the X chromosome; Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein |
| Protein Family: | Lysine-specific demethylase |
| UniProt Gene Name: | KDM6A |
| UniProt Entry Name: | KDM6A_HUMAN |
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