[KD Validated] Raf1 Polyclonal Antibody

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SKU:
CAB23679
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:[KD Validated] Raf1 Polyclonal Antibody
Product Code:CAB23679
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:1000-1:5000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Positive Samples:293T, Mouse lung
Cellular Location:Cell membrane, Cytoplasm, Mitochondrion, Nucleus

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Immunogen:Recombinant protein of human Raf1.
Sequence:IRQLL LFPNS TIGDS GVPAL PSLTM RRMRE SVSRM PVSSQ HRYST PHAFT FNTSS PSSEG SLSQR QRSTS TPNVH MVSTT LPVDS RMIED AIRSH SESAS PSALS SSPNN LSPTG WSQPK TPVPA QRERA PVSGT QEKNK IRPRG QRDSS YYWEI EASEV M
Synonyms:NS5, CRAF, Raf-1, c-Raf, CMD1NN
Calculated MW:73kDa
Observed MW:75kDa
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