[KD Validated] Pin1 Monoclonal Antibody
![[KD Validated] Pin1 Monoclonal Antibody](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/82667/87454/A22470_1__64606__33988.1706547426.jpg?c=1 "[KD Validated] Pin1 Monoclonal Antibody")
- SKU:
- CAB22470
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
![[KD Validated] Pin1 Monoclonal Antibody](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/82667/87454/A22470_1__64606__33988.1706547426.jpg?c=1&imbypass=on "[KD Validated] Pin1 Monoclonal Antibody")
Description
| Product Name: | [KD Validated] Pin1 Monoclonal Antibody |
| Product Code: | CAB22470 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57311 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, 293T, NIH/3T3, Mouse brain, PC-12, Rat brain |
| Cellular Location: | Cytoplasm, Nucleus, Nucleus speckle |
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human Pin1 (NP_006212.1). |
| Sequence: | MADEE KLPPG WEKRM SRSSG RVYYF NHITN ASQWE RPSGN SSSGG KNGQG EPARV RCSHL LVKHS QSRRP SSWRQ EKITR TKEEA LELIN GYIQK IKSGE EDFES LASQF SDCSS AKARG DLGAF SRGQM QKPFE DASFA LRTGE MSGPV FTDSG IHIIL RTE |
| Synonyms: | DOD, UBL5 |
| Calculated MW: | 18kDa |
| Observed MW: | Refer to figures |
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