[KD Validated] PGC1α Polyclonal Antibody

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SKU:
CAB22113
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IHC

Description

Product Name:[KD Validated] PGC1α Polyclonal Antibody
Product Code:CAB22113
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, ELISA
Key Applications:Western blotting, Immunohistochemistry
Recommended Dilution:WB 1:100-1:500, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa, SH-SY5Y, Mouse skeletal muscle
Cellular Location:cytoplasm, nucleoplasm, nucleus, PML body

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 611-710 of human PGC1α (NP_037393.1).
Sequence:RTHRN SPLYV RSRSR SPYSR RPRYD SYEEY QHERL KREEY RREYE KRESE RAKQR ERQRQ KAIEE RRVIY VGKIR PDTTR TELRD RFEVF GEIEE CTVNL
Synonyms:LEM6, PGC1, PGC1A, PGC-1v, PPARGC1, PGC-1alpha, PGC-1(alpha)
Calculated MW:91kDa
Observed MW:100kDa
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