[KD Validated] NQO1 Monoclonal Antibody

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SKU:
CAB22290
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF

Description

Product Name:[KD Validated] NQO1 Monoclonal Antibody
Product Code:CAB22290
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC56754
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:2000-1:20000, IF/ICC 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa, HepG2, Mouse stomach, Rat lung, Rat stomach
Cellular Location:cytoplasm, cytosol, dendrite, synapse

This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human NQO1 (NP_000894.1).
Sequence:MVGRR ALIVL AHSER TSFNY AMKEA AAAAL KKKGW EVVES DLYAM NFNPI ISRKD ITGKL KDPAN FQYPA ESVLA YKEGH LSPDI VAEQK KLEAA DLVIF QFPLQ WFGVP AILKG WFERV FIGEF AYTYA AMYDK GPFRS KKAVL SITTG GSGSM YSLQG IHGDM NVILW PIQSG ILHFC GFQVL EPQLT YSIGH TPADA RIQIL EGWKK RLENI WDETP LYFAP SSLFD LNFQA GFLMK KEVQD EEKNK KFGLS VGHHL GKSIP TDNQI KARK
Synonyms:DTD, QR1, DHQU, DIA4, NMOR1, NMORI
Calculated MW:31kDa
Observed MW:31kDa
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