[KD Validated] MAD1/MAD1L1 Polyclonal Antibody

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SKU:
CAB22000
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:[KD Validated] MAD1/MAD1L1 Polyclonal Antibody
Product Code:CAB22000
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:293T, HepG2
Cellular Location:centrosome, cytoplasm, cytosol, mitotic spindle, mitotic spindle assembly checkpoint MAD1-MAD2 complex, nuclear pore nuclear basket, nucleus, spindle, spindle pole

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 351-718 of human MAD1/MAD1L1 (NP_003541.2).
Sequence:KNSAV TSSAR GLEKA RQQLQ EELRQ VSGQL LEERK KRETH EALAR RLQKR VLLLT KERDG MRAIL GSYDS ELTPA EYSPQ LTRRM REAED MVQKV HSHSA EMEAQ LSQAL EELGG QKQRA DMLEM ELKML KSQSS SAEQS FLFSR EEADT LRLKV EELEG ERSRL EEEKR MLEAQ LERRA LQGDY DQSRT KVLHM SLNPT SVARQ RLRED HSQLQ AECER LRGLL RAMER GGTVP ADLEA AAASL PSSKE VAELK KQVES AELKN QRLKE VFQTK IQEFR KACYT LTGYQ IDITT ENQYR LTSLY AEHPG DCLIF KATSP SGSKM QLLET EFSHT VGELI EVHLR RQDSI PAFLS SLTLE LFSRQ TVA
Synonyms:MAD1, MVA7, PIG9, TP53I9, TXBP181
Calculated MW:83kDa
Observed MW:83kDa
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