[KD Validated] IL13 Polyclonal Antibody

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SKU:
CAB22112
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:[KD Validated] IL13 Polyclonal Antibody
Product Code:CAB22112
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:MCF7
Cellular Location:cytoplasm, external side of plasma membrane, extracellular region, extracellular space

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 25-146 of human IL13 (NP_002179.2).
Sequence:LTCLG GFASP GPVPP STALR ELIEE LVNIT QNQKA PLCNG SMVWS INLTA GMYCA ALESL INVSG CSAIE KTQRM LSGFC PHKVS AGQFS SLHVR DTKIE VAQFV KDLLL HLKKL FREGQ FN
Synonyms:P600, IL-13
Calculated MW:16kDa
Observed MW:13-16kDa
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