[KD Validated] eIF4EBP1 Monoclonal Antibody

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SKU:
CAB23500
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF

Description

Product Name:[KD Validated] eIF4EBP1 Monoclonal Antibody
Product Code:CAB23500
Reactivity:Human, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC56864
Reactivity:Human, Rat
Tested Applications:WB, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:1000-1:5000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:HeLa
Cellular Location:Cytoplasm, Nuclear

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human eIF4EBP1 (NP_004086.1).
Sequence:MSGGS SCSQT PSRAI PATRR VVLGD GVQLP PGDYS TTPGG TLFST TPGGT RIIYD RKFLM ECRNS PVTKT PPRDL PTIPG VTSPS SDEPP MEASQ SHLRN
Synonyms:BP-1, 4EBP1, 4E-BP1, PHAS-I
Calculated MW:13kDa
Observed MW:20kDa
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