[KD Validated] eIF4E Polyclonal Antibody

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SKU:
CAB22681
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
Applications:
IF
Applications:
IHC

Description

Product Name:[KD Validated] eIF4E Polyclonal Antibody
Product Code:CAB22681
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence, Immunohistochemistry
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunofluorescence, Immunohistochemistry
Recommended Dilution:WB 1:100-1:500, IF/ICC 1:50-1:200, IHC-P 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:293T, HeLa, Jurkat, RAW264.7, NIH/3T3, PC-12
Cellular Location:chromatoid body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, extracellular exosome, glutamatergic synapse, nucleus, P-body, perinuclear region of cytoplasm, postsynaptic cytosol

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human eIF4E. (NP_001959.1).
Sequence:MATVE PETTP TPNPP TTEEE KTESN QEVAN PEHYI KHPLQ NRWAL WFFKN DKSKT WQANL RLISK FDTVE DFWAL YNHIQ LSSNL MPGCD YSLFK DGIEP
Synonyms:CBP, EIF4F, AUTS19, EIF4E1, eIF-4E, EIF4EL1
Calculated MW:25kDa
Observed MW:29kDa
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