KCTD6 Antibody (PACO38314)
- SKU:
- PACO38314
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KCTD6 Antibody (PACO38314) |
| Antibody SKU: | PACO38314 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human BTB/POZ domain-containing protein KCTD6 protein (1-237AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO38314 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO38314 at dilution of 1:100. |
| Background: | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation. |
| Synonyms: | BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6), KCTD6 |
| UniProt Protein Function: | KCTD6: Protein type: Unknown functionChromosomal Location of Human Ortholog: 3p14.3Molecular Function: ankyrin binding; protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8NC69 |
| NCBI GenInfo Identifier: | 115502243 |
| NCBI Gene ID: | 200845 |
| NCBI Accession: | Q8NC69.2 |
| UniProt Secondary Accession: | Q8NC69,Q8NBS6, Q8TCA6, B3KNI5 |
| UniProt Related Accession: | Q8NC69 |
| Molecular Weight: | 27,610 Da |
| NCBI Full Name: | BTB/POZ domain-containing protein KCTD6 |
| NCBI Synonym Full Names: | potassium channel tetramerization domain containing 6 |
| NCBI Official Symbol: | KCTD6 |
| NCBI Official Synonym Symbols: | KCASH3 |
| NCBI Protein Information: | BTB/POZ domain-containing protein KCTD6 |
| UniProt Protein Name: | BTB/POZ domain-containing protein KCTD6 |
| UniProt Synonym Protein Names: | |
| Protein Family: | BTB/POZ domain-containing protein |
| UniProt Gene Name: | KCTD6 |
| UniProt Entry Name: | KCTD6_HUMAN |
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