KCNV1 Antibody (PACO63807)
- SKU:
- PACO63807
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KCNV1 Antibody (PACO63807) |
| Antibody SKU: | PACO63807 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Potassium voltage-gated channel subfamily V member 1 protein (1-200AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of A549 cells with PACO63807 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. |
| Synonyms: | Potassium voltage-gated channel subfamily V member 1 (Neuronal potassium channel α subunit HNKA) (Voltage-gated potassium channel subunit Kv8.1), KCNV1 |
| UniProt Protein Function: | KCNV1: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 8q23.2Cellular Component: integral component of plasma membrane; plasma membrane; voltage-gated potassium channel complexMolecular Function: ion channel inhibitor activity; potassium channel regulator activity; voltage-gated potassium channel activityBiological Process: potassium ion transport; protein homooligomerization; regulation of molecular function |
| UniProt Protein Details: | |
| NCBI Summary: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6PIU1 |
| NCBI GenInfo Identifier: | 7657289 |
| NCBI Gene ID: | 27012 |
| NCBI Accession: | NP_055194 |
| UniProt Secondary Accession: | Q6PIU1 |
| UniProt Related Accession: | Q6PIU1 |
| Molecular Weight: | 56kDa |
| NCBI Full Name: | potassium voltage-gated channel subfamily V member 1 |
| NCBI Synonym Full Names: | potassium voltage-gated channel modifier subfamily V member 1 |
| NCBI Official Symbol: | KCNV1 |
| NCBI Official Synonym Symbols: | HNKA; KCNB3; KV2.3; KV8.1 |
| NCBI Protein Information: | potassium voltage-gated channel subfamily V member 1 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily V member 1 |
| UniProt Synonym Protein Names: | Neuronal potassium channel alpha subunit HNKA; Voltage-gated potassium channel subunit Kv8.1 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNV1 |
| UniProt Entry Name: |
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