Antibody Name:	KCNQ4 Antibody (PACO19895)
Antibody SKU:	PACO19895
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human KCNQ4

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19895(KCNQ4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, mouse brain tissue, Primary antibody: PACO19895(KCNQ4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 7 minutes.
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19895(KCNQ4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms:

potassium voltage-gated channel, KQT-like subfamily, member 4

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UniProt Code:	P56696
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UniProt Secondary Accession:	P56696
UniProt Related Accession:	P56696
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