Antibody Name:	KCNMB4 Antibody (PACO19891)
Antibody SKU:	PACO19891
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human KCNMB4

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19891(KCNMB4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO19891(KCNMB4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19891(KCNMB4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming α subunit and the modulatory β subunit. The protein encoded by this gene is an auxiliary β subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the β 1 subunit.

Synonyms:

potassium large conductance calcium-activated channel, subfamily M, β member 4

UniProt Protein Function:	JARID1B: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cancer Testis Antigen (CTA); Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 1q32.1Cellular Component: cytoplasm; nucleoplasm; nucleusMolecular Function: histone demethylase activity; histone demethylase activity (H3-K4 specific); protein binding; transcription corepressor activity; transcription factor activity
UniProt Protein Details:
NCBI Summary:	MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]
UniProt Code:	Q86W47
NCBI GenInfo Identifier:	26051275
NCBI Gene ID:	27345
NCBI Accession:	NP_055320
UniProt Secondary Accession:	Q86W47
UniProt Related Accession:	Q86W47
Molecular Weight:	24kDa
NCBI Full Name:	calcium-activated potassium channel subunit beta-4
NCBI Synonym Full Names:	potassium calcium-activated channel subfamily M regulatory beta subunit 4
NCBI Official Symbol:	KCNMB4
NCBI Official Synonym Symbols:
NCBI Protein Information:	calcium-activated potassium channel subunit beta-4
UniProt Protein Name:	Lysine-specific demethylase 5B
UniProt Synonym Protein Names:	Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; PLU-1; Retinoblastoma-binding protein 2 homolog 1; RBP2-H1
Protein Family:	Lysine-specific demethylase
UniProt Gene Name:	KDM5B
UniProt Entry Name: