KCNK3 Antibody (PACO20658)
- SKU:
- PACO20658
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KCNK3 Antibody (PACO20658) |
| Antibody SKU: | PACO20658 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human KCNK3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Mouse heart tissue, Primary antibody: PACO20658(KCNK3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20658(KCNK3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acid, fication. Also referred to as an acid, sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. |
| Synonyms: | potassium channel, two pore domain subfamily K, member 3 |
| UniProt Protein Function: | KCNK3: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassiumCellular Component: cytosol; integral to membrane; integral to plasma membrane; membrane; plasma membraneMolecular Function: ion channel activity; open rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activityBiological Process: ion transport; potassium ion transport; reduction of cytosolic calcium ion concentration; response to drug; stabilization of membrane potential; transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O35111 |
| NCBI GenInfo Identifier: | 33859576 |
| NCBI Gene ID: | 16527 |
| NCBI Accession: | NP_034738.1 |
| UniProt Secondary Accession: | O35111,O35163 |
| UniProt Related Accession: | O35111 |
| Molecular Weight: | 45,068 Da |
| NCBI Full Name: | potassium channel subfamily K member 3 |
| NCBI Synonym Full Names: | potassium channel, subfamily K, member 3 |
| NCBI Official Symbol: | Kcnk3 |
| NCBI Official Synonym Symbols: | TASK; Task-1; cTBAK-1 |
| NCBI Protein Information: | potassium channel subfamily K member 3 |
| UniProt Protein Name: | Potassium channel subfamily K member 3 |
| UniProt Synonym Protein Names: | Acid-sensitive potassium channel protein TASK-1; Cardiac two pore background K(+) channel; TWIK-related acid-sensitive K(+) channel 1; Two pore potassium channel KT3.1; Two pore K(+) channel KT3.1; cTBAK-1 |
| Protein Family: | Potassium channel subfamily |
| UniProt Gene Name: | Kcnk3 |
| UniProt Entry Name: | KCNK3_MOUSE |
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