KCNIP4 Antibody (PACO36894)
- SKU:
- PACO36894
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KCNIP4 Antibody (PACO36894) |
| Antibody SKU: | PACO36894 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Kv channel-interacting protein 4 protein (1-250AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO36894 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO36894 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. |
| Synonyms: | Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4), KCNIP4, CALP KCHIP4 |
| UniProt Protein Function: | KCNIP4: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Belongs to the recoverin family. 5 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 4p15.32Cellular Component: cytoplasm; cytosol; plasma membrane; voltage-gated potassium channel complexMolecular Function: calcium ion binding; potassium channel regulator activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6PIL6 |
| NCBI GenInfo Identifier: | 73621129 |
| NCBI Gene ID: | 80333 |
| NCBI Accession: | Q6PIL6.1 |
| UniProt Secondary Accession: | Q6PIL6,Q3YAB8, Q3YAB9, Q3YAC0, Q3YAC1, Q3YAC2, Q4W5G8 Q8NEU0, Q9BWT2, Q9H294 |
| UniProt Related Accession: | Q6PIL6 |
| Molecular Weight: | 26,267 Da |
| NCBI Full Name: | Kv channel-interacting protein 4 |
| NCBI Synonym Full Names: | potassium voltage-gated channel interacting protein 4 |
| NCBI Official Symbol: | KCNIP4 |
| NCBI Official Synonym Symbols: | CALP; KCHIP4 |
| NCBI Protein Information: | Kv channel-interacting protein 4 |
| UniProt Protein Name: | Kv channel-interacting protein 4 |
| UniProt Synonym Protein Names: | A-type potassium channel modulatory protein 4; Calsenilin-like protein |
| Protein Family: | Kv channel-interacting protein |
| UniProt Gene Name: | KCNIP4 |
| UniProt Entry Name: | KCIP4_HUMAN |
| Antibodies |
| KCNIP4 Antibody (PACO10055) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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