| Background: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. |
| Synonyms: | potassium voltage-gated channel, Shab-related subfamily, member 1 |
| UniProt Protein Function: | Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Channel, ligand-gatedChromosomal Location of Human Ortholog: 20q13.2Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; plasma membrane; integral to membraneMolecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus bindingBiological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerizationDisease: Epileptic Encephalopathy, Early Infantile, 26 |
| UniProt Protein Details: | |
| NCBI Summary: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14721 |
| NCBI GenInfo Identifier: | 24418854 |
| NCBI Gene ID: | 3745 |
| NCBI Accession: | Q14721.2 |
| UniProt Secondary Accession: | Q14721,Q14193 |
| UniProt Related Accession: | Q14721 |
| Molecular Weight: | 95,878 Da |
| NCBI Full Name: | Potassium voltage-gated channel subfamily B member 1 |
| NCBI Synonym Full Names: | potassium voltage-gated channel, Shab-related subfamily, member 1 |
| NCBI Official Symbol: | KCNB1 |
| NCBI Official Synonym Symbols: | DRK1; KV2.1; EIEE26; h-DRK1 |
| NCBI Protein Information: | potassium voltage-gated channel subfamily B member 1; h-DRK1 K(+) channel; potassium channel protein DRK1; delayed rectifier potassium channel 1; delayed rectifier potassium channel Kv2.1; voltage-gated potassium channel subunit Kv2.1 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily B member 1 |
| UniProt Synonym Protein Names: | Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNB1 |
| UniProt Entry Name: | KCNB1_HUMAN |
