Name: KCNA7 Antibody (PACO63467)
SKU: PACO63467
Availability: OutOfStock

Antibody Name:	KCNA7 Antibody (PACO63467)
Antibody SKU:	PACO63467
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:	Human
Immunogen:	Recombinant Human Potassium voltage-gated channel subfamily A member 7 protein (1-143AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

IHC image of PACO63467 diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Background:	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity).
Synonyms:	Potassium voltage-gated channel subfamily A member 7 (Voltage-gated potassium channel subunit Kv1.7), KCNA7

UniProt Protein Function:	Kv1.7: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.Protein type: Membrane protein, multi-passChromosomal Location of Human Ortholog: 19q13.3Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membraneMolecular Function: delayed rectifier potassium channel activityBiological Process: synaptic transmission; protein homooligomerization
UniProt Protein Details:
NCBI Summary:	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]
UniProt Code:	Q96RP8
NCBI GenInfo Identifier:	25952092
NCBI Gene ID:	3743
NCBI Accession:	NP_114092.2
UniProt Secondary Accession:	Q96RP8,Q9BYS4, A1KYX7
UniProt Related Accession:	Q96RP8
Molecular Weight:	50,559 Da
NCBI Full Name:	potassium voltage-gated channel subfamily A member 7
NCBI Synonym Full Names:	potassium channel, voltage gated shaker related subfamily A, member 7
NCBI Official Symbol:	KCNA7
NCBI Official Synonym Symbols:	HAK6; KV1.7
NCBI Protein Information:	potassium voltage-gated channel subfamily A member 7
UniProt Protein Name:	Potassium voltage-gated channel subfamily A member 7
UniProt Synonym Protein Names:	Voltage-gated potassium channel subunit Kv1.7
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCNA7
UniProt Entry Name:	KCNA7_HUMAN