Antibody Name:	KCNA7 Antibody (PACO19874)
Antibody SKU:	PACO19874
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human KCNA7

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19874(KCNA7 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, mouse kidney tissue, Primary antibody: PACO19874(KCNA7 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19874(KCNA7 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily.

Synonyms:

potassium voltage-gated channel, shaker-related subfamily, member 7

UniProt Protein Function:	Kv1.7: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.Protein type: Membrane protein, multi-passChromosomal Location of Human Ortholog: 19q13.3Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membraneMolecular Function: delayed rectifier potassium channel activityBiological Process: synaptic transmission; protein homooligomerization
UniProt Protein Details:
NCBI Summary:	Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008]
UniProt Code:	Q96RP8
NCBI GenInfo Identifier:	25952092
NCBI Gene ID:	3743
NCBI Accession:	NP_114092.2
UniProt Secondary Accession:	Q96RP8,Q9BYS4, A1KYX7
UniProt Related Accession:	Q96RP8
Molecular Weight:	50,559 Da
NCBI Full Name:	potassium voltage-gated channel subfamily A member 7
NCBI Synonym Full Names:	potassium channel, voltage gated shaker related subfamily A, member 7
NCBI Official Symbol:	KCNA7
NCBI Official Synonym Symbols:	HAK6; KV1.7
NCBI Protein Information:	potassium voltage-gated channel subfamily A member 7
UniProt Protein Name:	Potassium voltage-gated channel subfamily A member 7
UniProt Synonym Protein Names:	Voltage-gated potassium channel subunit Kv1.7
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	KCNA7
UniProt Entry Name:	KCNA7_HUMAN