KCNA6 Antibody (PACO27737)
- SKU:
- PACO27737
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | KCNA6 Antibody (PACO27737) |
| Antibody SKU: | PACO27737 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Potassium voltage-gated channel subfamily A member 6 protein (1-171AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO27737 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using PACO27737 at dilution of 1:100. |
| Background: | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of α subunits that are part of the channel. Channel properties are modulated by cytoplasmic β subunits that regulate the subcellular location of the α subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305). |
| Synonyms: | Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel HBK2) (Voltage-gated potassium channel subunit Kv1.6), KCNA6 |
| UniProt Protein Function: | Kv1.6: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 12p13Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane; integral to membraneMolecular Function: voltage-gated potassium channel activity; delayed rectifier potassium channel activityBiological Process: synaptic transmission; protein homooligomerization; potassium ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P17658 |
| NCBI GenInfo Identifier: | 116434 |
| NCBI Gene ID: | 3742 |
| NCBI Accession: | P17658.1 |
| UniProt Secondary Accession: | P17658 |
| UniProt Related Accession: | P17658 |
| Molecular Weight: | |
| NCBI Full Name: | Potassium voltage-gated channel subfamily A member 6 |
| NCBI Synonym Full Names: | potassium voltage-gated channel subfamily A member 6 |
| NCBI Official Symbol: | KCNA6 |
| NCBI Official Synonym Symbols: | HBK2; KV1.6; PPP1R96 |
| NCBI Protein Information: | potassium voltage-gated channel subfamily A member 6 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily A member 6 |
| UniProt Synonym Protein Names: | Voltage-gated potassium channel HBK2; Voltage-gated potassium channel subunit Kv1.6 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNA6 |
| UniProt Entry Name: | KCNA6_HUMAN |
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