JNK1 Polyclonal Antibody (CAB2462)
- SKU:
- CAB2462
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | JNK1 Polyclonal Antibody |
| Product Code: | CAB2462 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | U-87MG, HeLa, BT-474, Mouse liver, Mouse spleen, Rat brain, Rat heart |
| Cellular Location: | Cytoplasm, Nucleus |
| Customer Validation: | WB(Rattus norvegicus, Mus musculus, Homo sapiens) |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 245-345 of human JNK1 (NP_620635.1). |
| Sequence: | CPEFM KKLQP TVRTY VENRP KYAGY SFEKL FPDVL FPADS EHNKL KASQA RDLLS KMLVI DASKR ISVDE ALQHP YINVW YDPSE AEAPP PKIPD KQLDE R |
| Synonyms: | JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2 |
| Calculated MW: | 48kDa |
| Observed MW: | 48kDa |
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