JNK1/JNK3 Monoclonal Antibody (CAB22376)
- SKU:
- CAB22376
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | JNK1/JNK3 Monoclonal Antibody |
| Product Code: | CAB22376 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52817 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA, DB |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:2000-1:20000, IF/ICC 1:50-1:200, DB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, 293T, NIH/3T3, Neuro-2a, Mouse brain, C6 |
| Cellular Location: | Cytoplasm, Nucleus |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human JNK1 (NP_620637.1). |
| Sequence: | MGYKE NVDLW SVGCI MGEMV CHKIL FPGRD YIDQW NKVIE QLGTP CPEFM KKLQP TVRTY VENRP KYAGY SFEKL FPDVL FPADS EHNKL KASQA RDLLS K |
| Synonyms: | JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK |
| Calculated MW: | 35kDa/44kDa/48kDa |
| Observed MW: | 44kDa/54kDa |
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