JNK1/2/3 Polyclonal Antibody
- SKU:
- CAB18678
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Applications:
- IP
Description
| Product Name: | JNK1/2/3 Polyclonal Antibody |
| Product Code: | CAB18678 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200, IP 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | SH-SY5Y, Mouse brain, Rat brain |
| Cellular Location: | axon, basal dendrite, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, synapse |
| Customer Validation: | WB(Plant, Bos taurus) |
JNK belongs to MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1, JNK2, and JNK3
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-370 of human JNK1/2/3 (NP_620637.1). |
| Sequence: | MSRSK RDNNF YSVEI GDSTF TVLKR YQNLK PIGSG AQGIV CAAYD AILER NVAIK KLSRP FQNQT HAKRA YRELV LMKCV NHKNI IGLLN VFTPQ KSLEE FQDVY IVMEL MDANL CQVIQ MELDH ERMSY LLYQM LCGIK HLHSA GIIHR DLKPS NIVVK SDCTL KILDF GLART AGTSF MMTPY VVTRY YRAPE VILGM GYKEN VDLWS VGCIM GEMVC HKILF PGRDY IDQWN KVIEQ LGTPC PEFMK KLQPT VRTYV ENRPK YAGYS FEKLF PDVLF PADSE HNKLK ASQAR DLLSK MLVID ASKRI SVDEA LQHPY INVWY DPSEA EAPPP KIPDK QLDER EHTIE EWKEL IYKEV MDLEE RTKNG |
| Calculated MW: | 35kDa/44kDa/48kDa/27kDa/52kDa |
| Observed MW: | 46kDa/54kDa |
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