JMY Antibody (PACO00989)
- SKU:
- PACO00989
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | JMY Antibody |
| Antibody SKU: | PACO00989 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the C-terminal region of human JMY. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | JMY; Junction-mediating and -regulatory protein |
| UniProt Protein Function: | JMY: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. Belongs to the JMY family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 5q14.1 Cellular Component: leading edge; nucleoplasm; nucleus Molecular Function:protein binding; transcription coactivator activity Biological Process: cell cycle arrest; positive regulation of apoptosis; positive regulation of transcription factor activity; regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | Q8N9B5 |
| NCBI GenInfo Identifier: | 172045777 |
| NCBI Gene ID: | 133746 |
| NCBI Accession: | Q8N9B5.2 |
| UniProt Secondary Accession: | Q8N9B5,A1L4P5, B5MDS2, B5MDT0, |
| UniProt Related Accession: | Q8N9B5 |
| Molecular Weight: | 110,280 Da |
| NCBI Full Name: | Junction-mediating and -regulatory protein |
| NCBI Synonym Full Names: | junction mediating and regulatory protein, p53 cofactor |
| NCBI Official Symbol: | JMY |
| NCBI Official Synonym Symbols: | WHAMM2; WHDC1L3 |
| NCBI Protein Information: | junction-mediating and -regulatory protein |
| UniProt Protein Name: | Junction-mediating and -regulatory protein |
| Protein Family: | Junction-mediating and -regulatory protein |
| UniProt Gene Name: | JMY |
| UniProt Entry Name: | JMY_HUMAN |
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