JAGN1 Antibody (PACO37938)
- SKU:
- PACO37938
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | JAGN1 Antibody (PACO37938) |
| Antibody SKU: | PACO37938 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein jagunal homolog 1 protein (1-39AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: JAGN1 antibody at 3µg/ml + HL60 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 22 kDa. Observed band size: 22 kDa. |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO37938 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO37938 at dilution of 1:100. |
| Background: | Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. |
| Synonyms: | Protein jagunal homolog 1, JAGN1 |
| UniProt Protein Function: | JAGN1: May be required for endoplasmic reticulum organization. Belongs to the jagunal family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 3p25.2Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membraneMolecular Function: protein bindingBiological Process: defense response to fungus; endoplasmic reticulum organization and biogenesis; exocytosis; neutrophil differentiation; neutrophil mediated immunity; protein transport; vesicle-mediated transportDisease: Neutropenia, Severe Congenital, 6, Autosomal Recessive |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a transmembrane protein. It functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Mutations in this gene result in severe congenital neutropenia. [provided by RefSeq, Oct 2014] |
| UniProt Code: | Q8N5M9 |
| NCBI GenInfo Identifier: | 190014601 |
| NCBI Gene ID: | 84522 |
| NCBI Accession: | NP_115881 |
| UniProt Secondary Accession: | Q8N5M9,Q4KM64, Q5XKN4, Q2NKY9 |
| UniProt Related Accession: | Q8N5M9 |
| Molecular Weight: | |
| NCBI Full Name: | protein jagunal homolog 1 isoform a |
| NCBI Synonym Full Names: | jagunal homolog 1 |
| NCBI Official Symbol: | JAGN1 |
| NCBI Official Synonym Symbols: | SCN6; GL009 |
| NCBI Protein Information: | protein jagunal homolog 1 |
| UniProt Protein Name: | Protein jagunal homolog 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protein jagunal |
| UniProt Gene Name: | JAGN1 |
| UniProt Entry Name: | JAGN1_HUMAN |
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