Description
Product Name: | ITCH Polyclonal Antibody |
Product Code: | CAB17389 |
Reactivity: | Human, Mouse, Rat |
Applications: | Western blotting, Immunohistochemistry |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human, Mouse, Rat |
Tested Applications: | WB, IHC-P, ELISA |
Key Applications: | Western blotting, Immunohistochemistry |
Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:100 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
Positive Samples: | 293T, NIH/3T3, C6, Mouse lung |
Cellular Location: | cell cortex, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, nucleoplasm, plasma membrane |
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of ITCH (NP_001244066.1). |
Sequence: | MSDSG SQLGS MGSLT MKSQL QITVI SAKLK ENKKN WFGPS PYVEV TVDGQ SKKTE KCNNT NSPKW KQPLT VIVTP VSKLH FRVWS HQTLK SDVLL GTAAL DIYET LKSNN MKLEE VVVTL QLGGD KEPTE TIGDL SICLD GLQLE SEVVT NGETT |
Synonyms: | AIF4, AIP4, ADMFD, NAPP1 |
Calculated MW: | 103kDa |
Observed MW: | 100kDa |