IRS4 Antibody (PACO18114)
- SKU:
- PACO18114
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | IRS4 Antibody (PACO18114) |
| Antibody SKU: | PACO18114 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:10000, IHC:1:20-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human IRS4 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18114(IRS4 Antibody) at dilution 1/17, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation |
| Synonyms: | insulin receptor substrate 4 |
| UniProt Protein Function: | IRS4: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: Xq22.3Cellular Component: plasma membrane; cytosolMolecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity; phosphoinositide 3-kinase binding; insulin receptor bindingBiological Process: regulation of lipid metabolic process; positive regulation of signal transduction; insulin receptor signaling pathway; signal transduction |
| UniProt Protein Details: | |
| NCBI Summary: | IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14654 |
| NCBI GenInfo Identifier: | 4504733 |
| NCBI Gene ID: | 8471 |
| NCBI Accession: | NP_003595.1 |
| UniProt Secondary Accession: | O14654 |
| UniProt Related Accession: | O14654 |
| Molecular Weight: | 133,768 Da |
| NCBI Full Name: | insulin receptor substrate 4 |
| NCBI Synonym Full Names: | insulin receptor substrate 4 |
| NCBI Official Symbol: | IRS4 |
| NCBI Official Synonym Symbols: | IRS-4; PY160 |
| NCBI Protein Information: | insulin receptor substrate 4 |
| UniProt Protein Name: | Insulin receptor substrate 4 |
| UniProt Synonym Protein Names: | 160 kDa phosphotyrosine protein; py160; Phosphoprotein of 160 kDa; pp160 |
| Protein Family: | Insulin receptor substrate |
| UniProt Gene Name: | IRS4 |
| UniProt Entry Name: | IRS4_HUMAN |
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