IRP2 Monoclonal Antibody
- SKU:
- CAB22283
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | IRP2 Monoclonal Antibody |
| Product Code: | CAB22283 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55070 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:200-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | A549, 293T, Mouse lung, Rat kidney, Rat liver |
| Cellular Location: | Cytoplasm |
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-963 of human IRP2 (NP_004127.2). |
| Sequence: | SLEAP DSVLF PWDLK STYIR CPSFF DKLTK EPIAL QAIEN AHVLL YLGDS VTTDH ISPAG SIARN SAAAK YLTNR GLTPR EFNSY GARRG NDAVM TRGTF ANIKL FNKFI GKPAP KTIHF PSGQT LDVFE AAELY QKEGI PLIIL AGKKY GSGNS RDWAA KGPYL LGVKA VLAES YEKIH KDHLI GIGIA PLQFL PGENA DSLGL SGRET FSLTF PEELS PGITL NIQTS TGKVF SVIAS FEDDV EITLY KHGGL LNFVA RKFS |
| Synonyms: | ACO3, IRP2, IRP2AD, NDCAMA, IRE-BP2, IRE-BP 2 |
| Calculated MW: | 105kDa |
| Observed MW: | 105kDa |
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