IRGM Polyclonal Antibody (CAB8291)
- SKU:
- CAB8291
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | IRGM Polyclonal Antibody |
| Product Code: | CAB8291 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brain, Rat brain |
| Cellular Location: | Cell membrane, Cell projection, Cytoplasmic vesicle, Golgi apparatus membrane, autophagosome membrane, phagocytic cup, phagosome membrane |
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human IRGM (NP_001139277.1). |
| Sequence: | MEAMN VEKAS ADGNL PEVIS NIKET LKIVS RTPVN ITMAG DSGNG MSTFI SALRN TGHEG KASPP TELVK ATQRC ASYFS SHFSN VVLWD LPGTG SATTT LENYL MEMQF NRYDF IMVAS AQFSM NHVML AKTAE DMGKK FYIVW TKLDM DLSTG ALPEV QLLQI RENVL ENLQK ERVCE Y |
| Synonyms: | IFI1, IBD19, IRGM1, LRG47, LRG-47 |
| Calculated MW: | 20kDa |
| Observed MW: | 30kDa |
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