Irf8 Antibody (PACO27665)
- SKU:
- PACO27665
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Irf8 Antibody (PACO27665) |
| Antibody SKU: | PACO27665 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Interferon regulatory factor 8 protein (1-424AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Irf8 antibody at 2µg/ml + Raji whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 49 kDa Observed band size: 49 kDa . |
| Background: | Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes. |
| Synonyms: | Interferon regulatory factor 8 (IRF-8) (Interferon consensus sequence-binding protein) (ICSBP), Irf8, Icsbp Icsbp1 |
| UniProt Protein Function: | IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family.Protein type: Transcription factor; DNA-bindingCellular Component: nucleoplasm; nucleusMolecular Function: protein binding; DNA binding; transcription factor activityBiological Process: positive regulation of interferon-gamma production; response to bacterium; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of interleukin-12 production; positive regulation of transcription, DNA-dependent; defense response to bacterium; immune response; myeloid cell differentiation; defense response to protozoan; phagocytosis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P23611 |
| NCBI GenInfo Identifier: | 6680339 |
| NCBI Gene ID: | 15900 |
| NCBI Accession: | NP_032346.1 |
| UniProt Secondary Accession: | P23611 |
| UniProt Related Accession: | P23611 |
| Molecular Weight: | 48,237 Da |
| NCBI Full Name: | interferon regulatory factor 8 |
| NCBI Synonym Full Names: | interferon regulatory factor 8 |
| NCBI Official Symbol: | Irf8 |
| NCBI Official Synonym Symbols: | Myls; ICSBP; IRF-8; Icsbp1; AI893568 |
| NCBI Protein Information: | interferon regulatory factor 8; interferon consensus sequence-binding protein; interferon consensus sequence binding protein 1 |
| UniProt Protein Name: | Interferon regulatory factor 8 |
| UniProt Synonym Protein Names: | Interferon consensus sequence-binding protein; ICSBP |
| Protein Family: | Interferon regulatory factor |
| UniProt Gene Name: | Irf8 |
| UniProt Entry Name: | IRF8_MOUSE |
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