IRF3 Monoclonal Antibody [P3F10AT] (CPAB0062)
![IRF3 Monoclonal Antibody [P3F10AT] (CPAB0062)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58291/63473/irf3-monoclonal-antibody-p3f10at-cpab0062__18293__60377.1706534960.jpg?c=1 "IRF3 Monoclonal Antibody [P3F10AT] (CPAB0062)")
- SKU:
- CPAB0062
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- P3F10AT
- Applications:
- WB
- Applications:
- ELISA
![IRF3 Monoclonal Antibody [P3F10AT] (CPAB0062)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58291/63473/irf3-monoclonal-antibody-p3f10at-cpab0062__18293__60377.1706534960.jpg?c=1&imbypass=on "IRF3 Monoclonal Antibody [P3F10AT] (CPAB0062)")
Description
system_update_alt Datasheet
| Product Name: | IRF3 Antibody |
| Product Sku: | CPAB0062 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human IRF3 mAb, is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human IRF3 amino acids 18-166 purified from Ecoli. |
| Clone: | P3F10AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA |
| Purification Method: | IRF3 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG1 |
| Background: | Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn |
| Synonyms: | IRF-3, IRF3, Interferon Regulatory Factor 3. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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