IRF3 Antibody (PACO48970)
- SKU:
- PACO48970
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | IRF3 Antibody (PACO48970) |
| Antibody SKU: | PACO48970 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human IRF3 protein (1-191AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: THP-1 whole cell lysate, A549 whole cell lysate. All lanes: IRF3 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 50 kDa. Observed band size: 50 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO48970 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO48970 at dilution of 1:100. |
| Synonyms: | IRF3 protein (Interferon regulatory factor 3, isoform CRA_b), IRF3 |
| UniProt Protein Function: | IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 19q13.3-q13.4Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosolMolecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription cofactor activity; transcription factor activityBiological Process: transcription from RNA polymerase II promoter; negative regulation of interferon-beta biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; MyD88-independent toll-like receptor signaling pathway; cytokine and chemokine mediated signaling pathway; negative regulation of defense response to virus by host; toll-like receptor 3 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; response to exogenous dsRNA; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon type I production; positive regulation of interferon-beta production; innate immune response; interferon type I biosynthetic process; response to DNA damage stimulus; defense response to virus; toll-like receptor 4 signaling pathway; negative regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of cytokine secretionDisease: Herpes Simplex Encephalitis, Susceptibility To, 7 |
| UniProt Protein Details: | |
| NCBI Summary: | IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants have been described. [provided by RefSeq] |
| UniProt Code: | Q96GL3 |
| NCBI GenInfo Identifier: | 1107689 |
| NCBI Gene ID: | 3661 |
| NCBI Accession: | |
| UniProt Secondary Accession: | Q96GL3,A8K7L2 |
| UniProt Related Accession: | Q96GL3,Q14653, Q5FBY1, Q5FBY2, Q5FBY4, Q71U93, Q7Z5G6, Q96GL3 |
| Molecular Weight: | 47,219 Da |
| NCBI Full Name: | interferon regulatory factor 3 |
| NCBI Synonym Full Names: | interferon regulatory factor 3 |
| NCBI Official Symbol: | IRF3 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | interferon regulatory factor 3; IRF-3 |
| UniProt Protein Name: | Interferon regulatory factor 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Interferon regulatory factor |
| UniProt Gene Name: | IRF3 |
| UniProt Entry Name: | IRF3_HUMAN |
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