IRE1 Monoclonal Antibody
- SKU:
- CAB21021
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | IRE1 Monoclonal Antibody |
| Product Code: | CAB21021 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57190 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, LNCaP, SK-N-SH(Low expression control), C2C12, Mouse thymus, Rat brain |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type I membrane protein |
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 286-435 of human IRE1 (NP_001424.3). |
| Sequence: | VGKYS TSLYA SPSMV HEGVA VVPRG STLPL LEGPQ TDGVT IGDKG ECVIT PSTDV KFDPG LKSKN KLNYL RNYWL LIGHH ETPLS ASTKM LERFP NNLPK HRENV IPADS EKKSF EEVIN LVDQT SENAP TTVSR DVEEK PAHAP ARPEA |
| Synonyms: | IRE1, IRE1P, IRE1a, hIRE1p |
| Calculated MW: | 110kDa |
| Observed MW: | 130kDa |
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