IRAK1BP1 Antibody (PACO14603)
- SKU:
- PACO14603
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | IRAK1BP1 Antibody (PACO14603) |
| Antibody SKU: | PACO14603 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human IRAK1BP1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14603(IRAK1BP1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: PACO14603(IRAK1BP1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO14603(IRAK1BP1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid, protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-α induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active. |
| Synonyms: | interleukin-1 receptor-associated kinase 1 binding protein 1 |
| UniProt Protein Function: | IRAK1BP1: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity. Belongs to the IRAK1BP1 family.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 6q14-q15Cellular Component: cytoplasm; nucleusBiological Process: I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; regulation of transcription, DNA-dependent; immune response |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5VVH5 |
| NCBI GenInfo Identifier: | 74747244 |
| NCBI Gene ID: | 134728 |
| NCBI Accession: | Q5VVH5.1 |
| UniProt Secondary Accession: | Q5VVH5 |
| UniProt Related Accession: | Q5VVH5 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-1 receptor-associated kinase 1-binding protein 1 |
| NCBI Synonym Full Names: | interleukin-1 receptor-associated kinase 1 binding protein 1 |
| NCBI Official Symbol: | IRAK1BP1 |
| NCBI Official Synonym Symbols: | AIP70; SIMPL |
| NCBI Protein Information: | interleukin-1 receptor-associated kinase 1-binding protein 1; ActA binding protein 3; IRAK1-binding protein 1 |
| UniProt Protein Name: | Interleukin-1 receptor-associated kinase 1-binding protein 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Interleukin-1 receptor-associated kinase 1-binding protein |
| UniProt Gene Name: | IRAK1BP1 |
| UniProt Entry Name: | IKBP1_HUMAN |
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