| UniProt Protein Function: | IPPK: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. Belongs to the IPK1 type 2 family.Protein type: Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.158; Kinase, otherChromosomal Location of Human Ortholog: 9q22.31Cellular Component: nucleoplasm; intracellular; cytosolMolecular Function: inositol pentakisphosphate 2-kinase activity; ATP bindingBiological Process: inositol phosphate metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q9H8X2 |
| NCBI GenInfo Identifier: | 74752731 |
| NCBI Gene ID: | 64768 |
| NCBI Accession: | Q9H8X2.1 |
| UniProt Secondary Accession: | Q9H8X2,Q5T9F7, Q9H7V8 |
| UniProt Related Accession: | Q9H8X2 |
| Molecular Weight: | |
| NCBI Full Name: | Inositol-pentakisphosphate 2-kinase |
| NCBI Synonym Full Names: | inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
| NCBI Official Symbol: | IPPK |
| NCBI Official Synonym Symbols: | IP5K; IPK1; C9orf12; INSP5K2; bA476B13.1 |
| NCBI Protein Information: | inositol-pentakisphosphate 2-kinase; IPK1 homolog; bA476B13.1 (novel protein); ins(1,3,4,5,6)P5 2-kinase; insP5 2-kinase |
| UniProt Protein Name: | Inositol-pentakisphosphate 2-kinase |
| UniProt Synonym Protein Names: | IPK1 homolog; Inositol-1,3,4,5,6-pentakisphosphate 2-kinase; Ins(1,3,4,5,6)P5 2-kinase; InsP5 2-kinase |
| Protein Family: | |
| UniProt Gene Name: | IPPK |
| UniProt Entry Name: | IPPK_HUMAN |
