UniProt Protein Function: | INTS3: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 3 family. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: integrator complex; nucleus Molecular Function:protein binding Biological Process: DNA repair; mitotic cell cycle checkpoint; response to DNA damage stimulus; response to ionizing radiation; snRNA processing |
NCBI Summary: | INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010] |
UniProt Code: | Q68E01 |
NCBI GenInfo Identifier: | 39995084 |
NCBI Gene ID: | 65123 |
NCBI Accession: | NP_075391.3 |
UniProt Secondary Accession: | Q68E01,Q4G0E5, Q5VUQ5, Q5VUQ6, Q5VUR0, Q5VUR1, Q68DJ1 Q69YR5, A8K1W0, B4DQC8, B4E3U9, D3DV57, |
UniProt Related Accession: | Q68E01 |
Molecular Weight: | 63,586 Da |
NCBI Full Name: | integrator complex subunit 3 |
NCBI Synonym Full Names: | integrator complex subunit 3 |
NCBI Official Symbol: | INTS3 |
NCBI Official Synonym Symbols: | INT3; SOSSA; SOSS-A; C1orf60; C1orf193 |
NCBI Protein Information: | integrator complex subunit 3 |
UniProt Protein Name: | Integrator complex subunit 3 |
UniProt Synonym Protein Names: | SOSS complex subunit A; Sensor of single-strand DNA complex subunit A; SOSS-A; Sensor of ssDNA subunit A |
Protein Family: | Integrator complex |
UniProt Gene Name: | INTS3 |
UniProt Entry Name: | INT3_HUMAN |