INTS1 Antibody (PACO19164)
- SKU:
- PACO19164
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | INTS1 Antibody (PACO19164) |
| Antibody SKU: | PACO19164 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human INTS1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19164(INTS1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit and mediates 3-prime end processing of small nuclear RNAs U1 and U2. RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. |
| Synonyms: | integrator complex subunit 1 |
| UniProt Protein Function: | INTS1: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 1 family.Protein type: RNA processing; Membrane protein, integralChromosomal Location of Human Ortholog: 7p22.3Cellular Component: nuclear membrane; membrane; integral to membrane; integrator complexBiological Process: snRNA processing; negative regulation of caspase activity; inner cell mass cell proliferation |
| UniProt Protein Details: | |
| NCBI Summary: | INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8N201 |
| NCBI GenInfo Identifier: | 97052424 |
| NCBI Gene ID: | 26173 |
| NCBI Accession: | Q8N201.2 |
| UniProt Secondary Accession: | Q8N201,Q6NT70, Q6UX74, Q8WV40, Q96D36, Q9NTD1, Q9P2A8 Q9Y3W8, A6NJ44 |
| UniProt Related Accession: | Q8N201 |
| Molecular Weight: | 244,297 Da |
| NCBI Full Name: | Integrator complex subunit 1 |
| NCBI Synonym Full Names: | integrator complex subunit 1 |
| NCBI Official Symbol: | INTS1 |
| NCBI Official Synonym Symbols: | INT1; NET28 |
| NCBI Protein Information: | integrator complex subunit 1 |
| UniProt Protein Name: | Integrator complex subunit 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Integrator complex |
| UniProt Gene Name: | INTS1 |
| UniProt Entry Name: | INT1_HUMAN |
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