Antibody Name:	Intermediate capsid protein VP6 Antibody (PACO35206)
Antibody SKU:	PACO35206
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Rotavirus A
Immunogen:	Recombinant Rotavirus A Intermediate capsid protein VP6 protein (1-397AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP.

Synonyms:

Intermediate capsid protein VP6

UniProt Protein Function:	Intermediate capsid protein that self assembles to form an icosahedral capsid with a T=13 symmetry, which consists of 230 trimers of VP6, with channels at each of its five-fold vertices. This capsid constitutes the middle concentric layer of the viral mature particle. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels at the five-fold axes. VP6 is required for the transcription activity of the DLP ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:	B1NKU0
NCBI GenInfo Identifier:	226698056
NCBI Gene ID:
NCBI Accession:	B1NKU0.1
UniProt Secondary Accession:	B1NKU0
UniProt Related Accession:	B1NKU0
Molecular Weight:	46.9 kDa
NCBI Full Name:	Intermediate capsid protein VP6
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:	Intermediate capsid protein VP6
UniProt Synonym Protein Names:
Protein Family:	Intermediate capsid protein
UniProt Gene Name:
UniProt Entry Name:	VP6_ROTHT