Interferon alpha 2 (IFN-α2） Monoclonal Antibody (CAB21263)
- SKU:
- CAB21263
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | Interferon alpha 2 (IFN-α2） Monoclonal Antibody |
| Product Code: | CAB21263 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53291 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:2000-1:6000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T-Interferon alpha 2 (IFN-α2) |
| Cellular Location: | Extracellular region, Extracellular space |
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-188 of human Interferon alpha 2 (IFN-α2） (NP_000596.2). |
| Sequence: | CDLPQ THSLG SRRTL MLLAQ MRRIS LFSCL KDRHD FGFPQ EEFGN QFQKA ETIPV LHEMI QQIFN LFSTK DSSAA WDETL LDKFY TELYQ QLNDL EACVI QGVGV TETPL MKEDS ILAVR KYFQR ITLYL KEKKY SPCAW EVVRA EIMRS FSLST NLQES LRSKE |
| Synonyms: | IFNA, IFNA2B, leIF A, IFN-alphaA, IFN-alpha-2 |
| Calculated MW: | 22kDa |
| Observed MW: | 20kDa |
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