Integrin beta 4 (ITGB4/CD104) Polyclonal Antibody
- SKU:
- CAB21469
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Integrin beta 4 (ITGB4/CD104) Polyclonal Antibody |
| Product Code: | CAB21469 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Cellular Location: | Cell junction, Cell membrane, Lipid-anchor, Single-pass type I membrane protein, hemidesmosome |
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-310 of human Integrin beta 4 (ITGB4/CD104) (NP_000204.3). |
| Sequence: | NRCKK APVKS CTECV RVDKD CAYCT DEMFR DRRCN TQAEL LAAGC QRESI VVMES SFQIT EETQI DTTLR RSQMS PQGLR VRLRP GEERH FELEV FEPLE SPVDL YILMD FSNSM SDDLD NLKKM GQNLA RVLSQ LTSDY TIGFG KFVDK VSVPQ TDMRP EKLKE PWPNS DPPFS FKNVI SLTED VDEFR NKLQG ERISG NLDAP EGGFD AILQT AVCTR DIGWR PDSTH LLVFS TESAF HYEAD GANVL AGIMS RNDER CHLDT TGTYT QYRTQ DYPSV PTL |
| Synonyms: | CD104, GP150, JEB5A, JEB5B |
| Calculated MW: | 202kDa |
| Observed MW: | Refer to figures |
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