Integrin alpha 5 (ITGA5/CD49e) Polyclonal Antibody (CAB22018)

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SKU:
CAB22018
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:Integrin alpha 5 (ITGA5/CD49e) Polyclonal Antibody
Product Code:CAB22018
Reactivity:Human, Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:A-549, HeLa, NIH/3T3, C2C12
Cellular Location:cytoplasmic vesicle, endoplasmic reticulum, external side of plasma membrane, glutamatergic synapse, Golgi apparatus, plasma membrane, postsynaptic membrane

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 42-995 of human Integrin alpha 5 (ITGA5/CD49e) (NP_002196.4).
Sequence:FNLDA EAPAV LSGPP GSFFG FSVEF YRPGT DGVSV LVGAP KANTS QPGVL QGGAV YLCPW GASPT QCTPI EFDSK GSRLL ESSLS SSEGE EPVEY KSLQW FGATV RAHGS SILAC APLYS WRTEK EPLSD PVGTC YLSTD NFTRI LEYAP CRSDF SWAAG QGYCQ GGFSA EFTKT GRVVL GGPGS YFWQG QILSA TQEQI AESYY PEYLI NLVQG QLQTR QASSI YDDSY LGYSV AVGEF SGDDT EDFVA GVPKG NLTYG YVTIL NGSDI RSLYN FSGEQ MASYF GYAVA ATDVN GDGLD DLLVG APLLM DRTPD GRPQE VGRVY VYLQH PAGIE PTPTL TLTGH DEFGR FGSSL TPLGD LDQDG YNDVA IGAPF GGETQ QGVVF VFPGG PGGLG SKPSQ VLQPL WAASH TPDFF GSALR GGRDL DGNGY PDLIV GSFGV DKAVV YRGRP IVSAS ASLTI FPAMF NPEER SCSLE GNPVA CINLS FCLNA SGKHV ADSIG FTVEL QLDWQ KQKGG VRRAL FLASR QATLT QTLLI QNGAR EDCRE MKIYL RNESE FRDKL SPIHI ALNFS LDPQA PVDSH GLRPA LHYQS KSRIE DKAQI LLDCG EDNIC VPDLQ LEVFG EQNHV YLGDK NALNL TFHAQ NVGEG GAYEA ELRVT APPEA EYSGL VRHPG NFSSL SCDYF AVNQS RLLVC DLGNP MKAGA SLWGG LRFTV PHLRD TKKTI QFDFQ ILSKN LNNSQ SDVVS FRLSV EAQAQ VTLNG VSKPE AVLFP VSDWH PRDQP QKEED LGPAV HHVYE LINQG PSSIS QGVLE LSCPQ ALEGQ QLLYV TRVTG LNCTT NHPIN PKGLE LDPEG SLHHQ QKREA PSRSS ASSGP QILKC PEAEC FRLRC ELGPL HQQES QSLQL HFRVW AKTFL QREHQ PFSLQ CEAVY KALKM PYRIL PRQLP QKERQ VATAV QWTKA EGSY
Synonyms:FNRA, CD49e, VLA-5, VLA5A
Calculated MW:115kDa
Observed MW:150kDa
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