Insulin Receptor Polyclonal Antibody (CAB21466)
- SKU:
- CAB21466
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Insulin Receptor Polyclonal Antibody |
| Product Code: | CAB21466 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HCT116, Mouse liver, Rat liver, 293T |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 475-570 of human Insulin Receptor (NP_000199.2). |
| Sequence: | TKGRQ ERNDI ALKTN GDQAS CENEL LKFSY IRTSF DKILL RWEPY WPPDF RDLLG FMLFY KEAPY QNVTE FDGQD ACGSN SWTVV DIDPP LRSND P |
| Synonyms: | HHF5, CD220 |
| Calculated MW: | 156kDa |
| Observed MW: | 95kDa |
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