| UniProt Protein Function: | Enoyl-ACP reductase of the type II fatty acid syntase (FAS-II) system, which is involved in the biosynthesis of mycolic acids, a major component of mycobacterial cell walls (PubMed:25227413). Catalyzes the NADH-dependent reduction of the double bond of 2-trans-enoyl-[acyl-carrier protein], an essential step in the fatty acid elongation cycle of the FAS-II pathway (PubMed:7599116). Shows preference for long-chain fatty acyl thioester substrates (>C16), and can also use 2-trans-enoyl-CoAs as alternative substrates (PubMed:7599116). The mycobacterial FAS-II system utilizes the products of the FAS-I system as primers to extend fatty acyl chain lengths up to C56, forming the meromycolate chain that serves as the precursor for final mycolic acids (PubMed:25227413). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P9WGR1 |
| NCBI GenInfo Identifier: | 15608622 |
| NCBI Gene ID: | 886523 |
| NCBI Accession: | NP_216000.1 |
| UniProt Secondary Accession: | P9WGR1,P0A5Y6, P46533, Q540M9, F2GEM2 |
| UniProt Related Accession: | P9WGR1 |
| Molecular Weight: | 28,528 Da |
| NCBI Full Name: | NADH-dependent enoyl-[ACP] reductase |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | inhA |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | NADH-dependent enoyl-[ACP] reductase |
| UniProt Protein Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] |
| UniProt Synonym Protein Names: | NADH-dependent enoyl-ACP reductase |
| Protein Family: | Inhibin |
| UniProt Gene Name: | inhA |
| UniProt Entry Name: | INHA_MYCTU |
