INCA1 Antibody (PACO35230)
- SKU:
- PACO35230
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | INCA1 Antibody (PACO35230) |
| Antibody SKU: | PACO35230 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein INCA1 protein (1-236AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO35230 at dilution of 1:100. |
| Background: | Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity). Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity). |
| Synonyms: | Protein INCA1 (Inhibitor of CDK interacting with cyclin A1), INCA1 |
| UniProt Protein Function: | INCA1: Belongs to the INCA family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 17p13.2Cellular Component: cytoplasm; nucleusMolecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; cyclin bindingBiological Process: negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q0VD86 |
| NCBI GenInfo Identifier: | 269847505 |
| NCBI Gene ID: | 388324 |
| NCBI Accession: | NP_001161457.1 |
| UniProt Secondary Accession: | Q0VD86,Q6J273, Q6PKN9 |
| UniProt Related Accession: | Q0VD86 |
| Molecular Weight: | 26817 |
| NCBI Full Name: | protein INCA1 isoform 2 |
| NCBI Synonym Full Names: | inhibitor of CDK, cyclin A1 interacting protein 1 |
| NCBI Official Symbol: | INCA1 |
| NCBI Official Synonym Symbols: | HSD45 |
| NCBI Protein Information: | protein INCA1 |
| UniProt Protein Name: | Protein INCA1 |
| UniProt Synonym Protein Names: | Inhibitor of CDK interacting with cyclin A1 |
| Protein Family: | Protein |
| UniProt Gene Name: | INCA1 |
| UniProt Entry Name: | INCA1_HUMAN |
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