IL18 Monoclonal Antibody (CAB23076)
- SKU:
- CAB23076
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | IL18 Monoclonal Antibody |
| Product Code: | CAB23076 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC56557 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:2000-1:8000, IHC-P 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | U-2 OS, HeLa |
| Cellular Location: | Secreted, Cytoplasm |
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human IL18 (NP_001553.1). |
| Sequence: | MAAEP VEDNC INFVA MKFID NTLYF IAEDD ENLES DYFGK LESKL SVIRN LNDQV LFIDQ GNRPL FEDMT DSDCR DNAPR TIFII SMYKD SQPRG MAVTI SVKCE KISTL SCENK IISFK EMNPP DNIKD TKSDI IFFQR SVPGH DNKMQ FESSS YEGYF LACEK ERDLF KLILK KEDEL GDRSI MFTVQ NED |
| Synonyms: | IGIF, IL-18, IL-1g, IL1F4 |
| Calculated MW: | 22kDa |
| Observed MW: | 22kDa |
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