IL17E Monoclonal Antibody [YR-hIL17E] (CPAB0012)

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SKU:
CPAB0012
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
YR-hIL17E
Applications:
IP
Applications:
ELISA
Applications:
IHC

Description

system_update_alt Datasheet
Product Name:IL17E Antibody
Product Sku:CPAB0012
Size:500μg
Host Species:mouse
Immunogen:r.Human IL-17E
Clone:YR-hIL17E.
Reactivity:Human
Applications:Immuneprecipitation, ELISA, Immunohistochemistry
Purification Method:Protein A
Isotype:IgG2a
Background:IL-25 also called IL-17E cytokine has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation, and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn't induce allergic inflammation in vivo.
Synonyms:IL-25, IL-17E, IL17E, IL25, Interleukin-25.
Storage Buffer:In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
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