IL15 Monoclonal Antibody
- SKU:
- CAB23026
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | IL15 Monoclonal Antibody |
| Product Code: | CAB23026 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53689 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | cell surface, cytoplasm, cytosol, endosome, extracellular region, extracellular space, Golgi apparatus, nuclear speck, nucleoplasm |
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 49-162 of human IL15 (NP_000576.1). |
| Sequence: | NWVNV ISDLK KIEDL IQSMH IDATL YTESD VHPSC KVTAM KCFLL ELQVI SLESG DASIH DTVEN LIILA NNSLS SNGNV TESGC KECEE LEEKN IKEFL QSFVH IVQMF INTS |
| Synonyms: | IL-15 |
| Calculated MW: | 18kDa |
| Observed MW: | Refer to figures |
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